Excedrin Tension Headache Relief Caplets are a fast-acting, neck and shoulder pain relief quickly. Combining acetaminophen with caffeine, this headache medicine delivers an effective formula with both a pain reliever and an amplifier to treat the headaches associated with neck and shoulder pain caused by the tension and stress. These Excedrin caplets relieve minor pain caused by tension headaches and muscular aches. Get fast relief from your headache.